Danger of use of disopyramide in patients with hypertrophic obstructive cardiomyopathy. An electrophysiologic study.

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Safety of Outpatient Initiation of Disopyramide for Obstructive Hypertrophic Cardiomyopathy Patients

BACKGROUND Disopyramide is effective in ameliorating symptoms in patients with hypertrophic cardiomyopathy; however, its potential for proarrhythmic effect has raised concerns about its use in the ambulatory setting. The risk of initiating disopyramide in this manner has never been evaluated. METHODS AND RESULTS All charts of patients seen in the outpatient hypertrophic cardiomyopathy clinic ...

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Use of esmolol in a parturient with hypertrophic obstructive cardiomyopathy.

The physiological changes occurring during pregnancy and labour may reveal or exacerbate the symptoms of hypertrophic obstructive cardiomyopathy (HOCM). We describe the management of labour in a patient with severe HOCM during which esmolol, a short-acting beta adrenergic antagonist, was used together with extradural analgesia and invasive cardiovascular monitoring to achieve an assisted vagina...

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Electrophysiologic Effects of Disopyramide in Patients

Seventeen patients with first-degree or Mobitz I atrioventricular (AV) block and narrow QRS complexes underwent electrophysiologic drug testing before and after i.v. administration of disopyramide. Disopyramide did not significantly change the mean sinus cycle length (895 131 vs 877 119 msec), mean maximal sinuss node recovery time (1134 + 169 vs 1133 13 msec), mean atrial effective refractory ...

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ژورنال

عنوان ژورنال: Japanese Heart Journal

سال: 1988

ISSN: 0021-4868,1348-673X

DOI: 10.1536/ihj.29.115